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A phase III dose -escalation trial of vitamin D3 and calcium in multiple sclerosis. Burton JM 1Kimball S, Vieth R ea St Michael8217;s Hospital, Toronto, Canada. Low vitamin D status has been associated with multiple sclerosis (MS) prevalence and risk;. to assess the tolerability of high 8211; dose oral vitamin D prospectively, an open-label randomized prospective controlled 52-week trial matched patients with MS to treatment or control groups. Treatment patients received escalating vitamin D doses up to 40,000 IUday (280 000iuwk) over 28 weeks to raise serum 25-hydroxyvitamin D [25(OH)D] rapidly and assess tolerability, timodine cream over the counter uk viagra by 10,000 IUday (12 weeks). Calcium (1,200 mgday) was given throughout the trial. Endpoints were mean change in biochemical measures, biomarkers, relapse events, and Expanded Disability Status Scale (EDSS) score. RESULTS: Forty-nine patients (25 treatment, 24 control) were enrolled [mean age 40. 5 years, EDSS 1. 34, and 25(OH)D 78 nmolL].

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